Document Detail

Surface-modified liposomes: assessment and characterization for increased stability and prolonged blood circulation.
MedLine Citation:
PMID:  8242837     Owner:  NLM     Status:  MEDLINE    
Advances in therapeutic applications of liposomes have been achieved through surface modifications increasing their biological stability: reduced constituent exchange and leakage as well as reduced unwanted uptake by cells of the mononuclear phagocytic system. The recent conclusions obtained from in vivo and in vitro studies are reviewed with an emphasis on evaluating the methods used and thus the kinds of conclusions which can be drawn. A number of issues are raised as to the limitations of the methods employed. Steric stabilization, meaning reduction in particle interactions by a surface steric barrier, has been proposed as a theoretical basis for the results and some of the initial results testing this hypothesis are reviewed here with respect to identification of the extent to which physical properties of the surface coatings correlate with the biological properties. At this time it seems that no one method is ideal so that multiple measures give the best characterization.
M C Woodle
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  64     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-29     Completed Date:  1993-12-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  249-62     Citation Subset:  IM    
Liposome Technology, Inc., Menlo Park, CA 94025.
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MeSH Terms
Drug Stability
Glycolipids / metabolism
Liposomes / chemistry*,  metabolism*
Polyethylene Glycols
Structure-Activity Relationship
Surface Properties
Tissue Distribution
Reg. No./Substance:
0/Glycolipids; 0/Liposomes; 0/Polyethylene Glycols

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