| Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. | |
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MedLine Citation:
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PMID: 15878378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a general method for incorporating target ligands into the surface of biocompatible polyester poly(lactic-co-glycolic acid) (PLGA) 50/50 materials using fatty acids. Avidin-fatty acid conjugates were prepared and efficiently incorporated into PLGA. Avidin was chosen as an adaptor protein to facilitate the attachment of a variety of biotinylated ligands. We show that fatty acid preferentially associates with the hydrophobic PLGA matrix, rather than the external aqueous environment, facilitating a prolonged presentation of avidin over several weeks. We successfully applied this approach in both microspheres encapsulating a model protein, bovine serum albumin, and PLGA scaffolds fabricated by a salt-leaching method. Because of its ease, generality and flexibility, this strategy promises widespread utility in modifying the surface of PLGA-based materials for applications in drug delivery and tissue engineering. |
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Authors:
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Tarek M Fahmy; Robert M Samstein; Casey C Harness; W Mark Saltzman |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2005-04-18 |
Journal Detail:
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Title: Biomaterials Volume: 26 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-05-09 Completed Date: 2005-10-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 5727-36 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Yale University, PO Box 208284, New Haven, CT 06520, USA. Tarek.fahmy@yale.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Avidin / administration & dosage, analysis, chemistry* Coated Materials, Biocompatible / analysis, chemistry* Diffusion Drug Delivery Systems / methods* Fatty Acids / chemistry* Lactic Acid / analysis, chemistry* Materials Testing Microspheres Particle Size Polyesters / chemistry Polyglycolic Acid / analysis, chemistry* Polymers / analysis, chemistry* Surface Properties |
| Grant Support | |
ID/Acronym/Agency:
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EB00487/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Fatty Acids; 0/Polyesters; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 1405-69-2/Avidin; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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