Document Detail


Surface immunoglobulins on Burkitt's lymphoma biopsy cells from 91 patients.
MedLine Citation:
PMID:  14768699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred and fourteen biopsies from 91 cases of African Burkitt's lymphoma were examined by immunofluorescence methods for the presence of surface-associated mu, gamma, delta, kappa and lambda chains, as well as for the Fc region of gamma chains and for beta1C. Only 5% of the biopsies were surface-Ig-negative; 18% were negative for mu chains and 61% for gamma chains. Delta chain staining was absent, or borderline in a few tumors. Mu chains, gamma chains in a few highly reactive tumors and, in many cases, the predominant light chain seemed to be clonal markers. They gave no convincing evidence of more than one cell clone, either within single tumors or within syn- or metachronous tumors in one individual. Gamma chains in moderately stained tumors, Fc and beta1C correlated with each other and the first two reactivities decreased after incubation at low pH, indicating that their presence resulted from outside coating of the cells. The results indicated that one clone of B cells is involved in Burkitt's lymphoma in the large majority of cases. This clone is in a state of differentiation at which surface delta chains are not expressed. No prognostic information resulted from the analysis of the markers studied.
Authors:
P Gunvén; G Klein; E Klein; T Norin; S Singh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  25     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1980 Jun 
Date Detail:
Created Date:  2004-02-10     Completed Date:  2004-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  711-9     Citation Subset:  IM    
Affiliation:
Department of Tumor Biology, Karolinska Institutet, S-104 01 Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Bone Neoplasms / immunology,  pathology
Burkitt Lymphoma / immunology*,  pathology
Female
Fluorescent Antibody Technique, Direct
Fluorescent Antibody Technique, Indirect
Humans
Immunoglobulin Fc Fragments / analysis
Immunoglobulin G / analysis
Immunoglobulin gamma-Chains / analysis
Immunoglobulin mu-Chains / analysis
Maxillary Neoplasms / immunology,  pathology
Receptors, Antigen, B-Cell / analysis*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
N01 CP 33316/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin Fc Fragments; 0/Immunoglobulin G; 0/Immunoglobulin gamma-Chains; 0/Immunoglobulin mu-Chains; 0/Receptors, Antigen, B-Cell

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