Document Detail


Surface immunoglobulin light chain-positive acute lymphoblastic leukemia of FAB L1 or L2 type: a report of 6 cases in adults.
MedLine Citation:
PMID:  9704611     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute lymphoblastic leukemia (ALL) of B-cell lineage may be classified using the French-American-British (FAB) classification as L1, L2, or L3 type. L1 and L2 ALLs characteristically express terminal deoxynucleotidyl transferase (TdT) and are surface immunoglobulin (sIg)-negative. In contrast, L3 ALL is typically TdT-negative and sIg-positive. However, in a few large studies of children with ALL, sIg expression has been reported in less than 2% of L1 and L2 neoplasms. In these sIg-positive cases, IgM usually has been detected, with Ig light chain in a subset of tumors. Surface Ig expression in L1 or L2 ALL in adults is extremely rare; we found only 1 case report in the English literature. We report 6 cases of L1 or L2 ALL with an unusual immunophenotype arising in adults. In each tumor, the neoplastic cells expressed monotypic sIg light chain (4 lambda, 2 kappa) and TdT. Three tumors expressed CD34. Cytogenetic studies in 4 cases at diagnosis or relapse revealed no evidence of chromosomal translocations involving the c-myc locus, such as the t(8;14), t(2;8), or t(8;22). Three patients responded completely to chemotherapy and are alive; follow-up ranges from 18 to 57 months. Three patients died at 3, 13, and 14 months after diagnosis.
Authors:
M A Vasef; R K Brynes; J L Murata-Collins; D A Arber; L J Medeiros
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  110     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-04     Completed Date:  1998-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Pathology, City of Hope National Medical Center, Duarte, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Female
Follow-Up Studies
Humans
Immunoglobulin Light Chains / metabolism*
Immunohistochemistry
Immunophenotyping
Karyotyping
Male
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics,  metabolism*,  pathology
Surface Properties
Chemical
Reg. No./Substance:
0/Immunoglobulin Light Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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