| Surface immunoglobulin light chain-positive acute lymphoblastic leukemia of FAB L1 or L2 type: a report of 6 cases in adults. | |
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MedLine Citation:
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PMID: 9704611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute lymphoblastic leukemia (ALL) of B-cell lineage may be classified using the French-American-British (FAB) classification as L1, L2, or L3 type. L1 and L2 ALLs characteristically express terminal deoxynucleotidyl transferase (TdT) and are surface immunoglobulin (sIg)-negative. In contrast, L3 ALL is typically TdT-negative and sIg-positive. However, in a few large studies of children with ALL, sIg expression has been reported in less than 2% of L1 and L2 neoplasms. In these sIg-positive cases, IgM usually has been detected, with Ig light chain in a subset of tumors. Surface Ig expression in L1 or L2 ALL in adults is extremely rare; we found only 1 case report in the English literature. We report 6 cases of L1 or L2 ALL with an unusual immunophenotype arising in adults. In each tumor, the neoplastic cells expressed monotypic sIg light chain (4 lambda, 2 kappa) and TdT. Three tumors expressed CD34. Cytogenetic studies in 4 cases at diagnosis or relapse revealed no evidence of chromosomal translocations involving the c-myc locus, such as the t(8;14), t(2;8), or t(8;22). Three patients responded completely to chemotherapy and are alive; follow-up ranges from 18 to 57 months. Three patients died at 3, 13, and 14 months after diagnosis. |
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Authors:
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M A Vasef; R K Brynes; J L Murata-Collins; D A Arber; L J Medeiros |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 110 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-04 Completed Date: 1998-09-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 143-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Pathology, City of Hope National Medical Center, Duarte, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Follow-Up Studies Humans Immunoglobulin Light Chains / metabolism* Immunohistochemistry Immunophenotyping Karyotyping Male Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics, metabolism*, pathology Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Light Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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