| Surface-exposed calreticulin in the interaction between dying cells and phagocytes. | |
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MedLine Citation:
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PMID: 20958319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phagocytosis is essential for pathogen elimination and for the removal of apoptotic corpses, a process that has been long considered immunologically silent. The phagocytic uptake of apoptotic/necrotic cells involves a plethora of molecules, including immunoglobulins, lectins, components of the complement system (all of which act as opsonins), as well as the phospholipid phosphatidylserine (PS) and the endoplasmic reticulum chaperone calreticulin (CRT), both of which can be exposed on the surface of dying cells. For a long time, surface-exposed CRT was believed to participate in phagocytosis, mostly as a (co)receptor for specific opsonins. Recently, this view has been challenged by the observations that, similar to PS, CRT acts as a facultative recognition ligand on apoptotic cells, and that cytotoxic agents such as anthracyclines induce the exposure of CRT on the surface of dying tumor cells, thereby generating an engulfment signal that stimulates the uptake of apoptotic corpses and the presentation of the corresponding antigens by dendritic cells. Here, we summarize the current knowledge on the role of CRT and CRT-interacting proteins during corpse removal. |
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Authors:
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Isabelle Martins; Oliver Kepp; Lorenzo Galluzzi; Laura Senovilla; Frederic Schlemmer; Sandy Adjemian; Laurie Menger; Mickael Michaud; Laurence Zitvogel; Guido Kroemer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1209 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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INSERM, U848, Villejuif, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Calreticulin / metabolism* Humans Phagocytes / cytology, metabolism* Phagocytosis* Phosphatidylserines / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Calreticulin; 0/Phosphatidylserines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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