Document Detail


Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids.
MedLine Citation:
PMID:  23154390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.
Authors:
Shubin Jin; Xiaowei Ma; Huili Ma; Kaiyuan Zheng; Juan Liu; Shuai Hou; Jie Meng; Paul C Wang; Xiaochun Wu; Xing-Jie Liang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-15
Journal Detail:
Title:  Nanoscale     Volume:  5     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-20     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Diffusion
Gold / therapeutic use*
Humans
Hyperthermia, Induced / methods*
MCF-7 Cells
Materials Testing
Metal Nanoparticles / administration & dosage*,  chemistry*,  ultrastructure
Particle Size
Spheroids, Cellular / chemistry*,  drug effects*
Static Electricity
Surface Properties
Treatment Outcome
Grant Support
ID/Acronym/Agency:
2G12RR003048/RR/NCRR NIH HHS; G12 MD007597/MD/NIMHD NIH HHS; G12 RR003048/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
7440-57-5/Gold
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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