Document Detail

Surface chemical and physical modification in stent technology for the treatment of coronary artery disease.
MedLine Citation:
PMID:  22949314     Owner:  NLM     Status:  MEDLINE    
Coronary artery disease (CAD) kills millions of people every year. It results from a narrowing of the arteries (stenosis) supplying blood to the heart. This review discusses the merits and limitations of balloon angioplasty and stent implantation, the most common treatment options for CAD, and the pathophysiology associated with these treatments. The focus of the review is heavily placed on research efforts geared toward the modification of stent surfaces for the improvement of stent-vascular compatibility and the reduction in the occurrence of related pathophysiologies. Such modifications may be chemical or physical, both of which are surveyed here. Chemical modifications may be passive or active, while physical modification of stent surfaces can also provide suitable substrates to manipulate the responses of vascular cells (endothelial, smooth muscle, and fibroblast). The influence of micro- and nanostructured surfaces on the in vitro cell response is discussed. Finally, future perspectives on the combination of chemical and physical modifications of stent surfaces are also presented.
Feroze Nazneen; Grégoire Herzog; Damien W M Arrigan; Noel Caplice; Pasquale Benvenuto; Paul Galvin; Michael Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-30
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  100     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-05     Completed Date:  2013-01-15     Revised Date:  2013-06-10    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1989-2014     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Tyndall National Institute, Life Sciences Interface, University College Cork, Lee Maltings, Cork, Ireland.
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MeSH Terms
Angioplasty, Balloon, Coronary*
Coated Materials, Biocompatible / chemistry*
Coronary Artery Disease / therapy*
Nanostructures / chemistry*
Surface Properties
Reg. No./Substance:
0/Coated Materials, Biocompatible

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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