Document Detail


Surface and bulk modifications to photocrosslinked polyanhydrides to control degradation behavior.
MedLine Citation:
PMID:  10880076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A unique class of surface-eroding polyanhydrides was developed and explored for use in medical applications requiring high-strength biomaterials (e.g., orthopedics). In particular, dimethacrylated anhydride monomers were synthesized that photopolymerize quickly to render densely crosslinked polymer networks that degrade from the surface only by hydrolysis of labile anhydride linkages. Previous research on these materials has shown that the rate of hydrolysis of the degradable linkages is dependent on the hydrophobicity of the network composition. This article demonstrates the versatility in controlling the degradation process and resulting cellular response in these materials through the incorporation of new chemistries and the formation of polymer-polymer composite structures. Specifically, the rate of mass loss was controlled by the addition of hydrophobic linear polymers [e.g., poly(methyl methacrylate)] or monovinyl monomers based on hydrophobic natural components (e.g., cholesterol, steric acid). In addition, a newly established photografting method was used to modify the network surface chemistry with cholesterol- and stearic acid-based polymer grafts to control the degradation front and cellular interactions at the polymer-tissue interface. Finally, a porogen leaching method was used to form porous polyanhydride constructs, which can be subsequently filled with osteoblasts photoencapsulated in a hydrogel, as potential synthetic allograft materials for tissue engineering bone.
Authors:
A K Burkoth; J Burdick; K S Anseth
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  51     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  352-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Affiliation:
Department of Chemical Engineering, University of Colorado, Boulder, Colorado 80309-0424, USA.
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MeSH Terms
Descriptor/Qualifier:
Anhydrides / chemical synthesis*,  chemistry*
Biocompatible Materials / chemical synthesis*,  chemistry*
Biodegradation, Environmental
Biomechanics
Biomedical Engineering
Bone and Bones / surgery
Cross-Linking Reagents
Humans
Materials Testing
Microscopy, Electron, Scanning
Photochemistry
Polymers / chemical synthesis*,  chemistry*
Surface Properties
Grant Support
ID/Acronym/Agency:
AR44375/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Anhydrides; 0/Biocompatible Materials; 0/Cross-Linking Reagents; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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