| Surface and blood-contacting properties of alkylsiloxane monolayers supported on silicone rubber. | |
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MedLine Citation:
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PMID: 7622539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Self-assembled monolayers of alkylsiloxanes supported on polydimethyl siloxane (PDMS) rubber were used as model systems to study the relation between blood compatibility and surface chemistry. The inner lumen of PDMS tubes was first treated with an oxygen plasma. The resultant oxidized surfaces were postderivatized by reacting them with alkyltrichlorosilanes to form the monolayer films. The chemical properties of the monolayers were controlled by varying the head-group chemical compositions. Surface derivatization was verified using variable-angle X-ray photoelectron spectroscopy (XPS or ESCA). Blood compatibility was evaluated using a canine ex vivo arteriovenous series shunt model. Surfaces grafted with hydrophobic head-groups as -CH3 and -CF3 had significantly lower platelet and fibrinogen deposition than the surfaces composed of hydrophilic groups such as -CO2CH3, -(CH2CH2O)3COCH3, and -(OCH2CH2)3OH. |
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Authors:
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J H Silver; R W Hergenrother; J C Lin; F Lim; H B Lin; T Okada; M K Chaudhury; S L Cooper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 29 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-08-31 Completed Date: 1995-08-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 535-48 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, University of Wisconsin, Madison 53706, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials* Blood* Blood Coagulation Dimethylpolysiloxanes* Dogs Electron Probe Microanalysis Fibrinogen / metabolism Platelet Adhesiveness Silanes* Silicones* Surface Properties |
| Grant Support | |
ID/Acronym/Agency:
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HL-24046/HL/NHLBI NIH HHS; HL-47179/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Dimethylpolysiloxanes; 0/Silanes; 0/Silicones; 63148-62-9/baysilon; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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