Document Detail

Surface and biological evaluation of hydroxyapatite-based coatings on titanium deposited by different techniques.
MedLine Citation:
PMID:  11745517     Owner:  NLM     Status:  MEDLINE    
Hydroxyapatite coatings have been deposited on titanium cp by plasma spray, sol-gel, and sputtering techniques for dental implant applications. The latter two techniques are of current interest, as they allow coatings of micrometer dimensions to be deposited. Coating morphology, composition, and structure have been investigated by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). All coatings were homogeneous and exhibited a rough morphology suitable for implant applications. The sputtered (after annealing), plasma spray, and sol-gel coatings all showed diffraction peaks corresponding to hydroxyapatite. The surface contaminants were observed to be different for the different coating types. The sputtered coatings were found to have a composition most similar to hydroxyapatite; the sol-gel deposits also showed a high concentration of hydroxyl ions. A discrepancy in the Ca/P ratio was observed for the plasma spray coatings, and a small concentration of carbonate ions was found in the sputter-deposited coatings. The in vitro cell-culture studies using MG63 osteoblast-like cells demonstrated the ability of cells to proliferate on the materials tested. The sol-gel coating promotes higher cell growth, greater alkaline phosphatase activity, and greater osteocalcin production compared to the sputtered and plasma-sprayed coatings.
C Massaro; M A Baker; F Cosentino; P A Ramires; S Klose; E Milella
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  58     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Inc.
PASTIS-CNRSM, Biomaterial Unit, SS7 Appia km 7+300, Brindisi, Italy.
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MeSH Terms
Alkaline Phosphatase / analysis
Calcium / analysis
Cell Division / drug effects
Cells, Cultured / drug effects,  metabolism
Coated Materials, Biocompatible / chemistry*,  toxicity
Durapatite / chemistry*,  toxicity
Materials Testing
Metallurgy / methods*
Microscopy, Electron, Scanning
Osteoblasts / drug effects
Osteocalcin / biosynthesis
Phosphorus / analysis
Spectrum Analysis
Titanium / chemistry*
X-Ray Diffraction
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Gels; 0/Powders; 104982-03-8/Osteocalcin; 1306-06-5/Durapatite; 7440-32-6/Titanium; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC Phosphatase

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