| Surface area-volume relationships for the mastoid air cell system and tympanum in adult humans: Implications for mastoid function. | |
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MedLine Citation:
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PMID: 20450279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSIONS: The middle ear (ME) surface area/volume ratio (SA/V) is greater than that of the tympanum. The rate of ME pressure decrease is proportional to the ME SA/V. The mastoid air-cell system (MACS) will not function as an ME gas reserve unless the blood perfusion/surface area is much greater for the tympanum than the MACS and decreases as MACS volume increases. OBJECTIVE: To measure the MACS and tympanum surface areas and volumes and ascertain whether the MACS could function as an ME gas reserve. METHODS: Twenty adult subjects with a wide range of MACS volumes underwent CT of their MEs. The left and right surface areas and volumes of the tympanum and MACS were reconstructed and entered into a simple perfusion-limited model of transmucosal gas exchange. In this model the MACS would be a gas reserve if ME SA/V was less than the tympanum SA/V or equivalently, if their ratio was less than a critical value of 1. RESULTS: Both MACS and tympanum SA were linearly related to their volumes. MACS SA/V and the ME SA/V were significantly greater than those for the tympanum. Inputting the measured values into the model yielded a critical value of 1.4, which was significantly greater than 1. |
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Authors:
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J Douglas Swarts; Brendan M Cullen Doyle; Cuneyt M Alper; William J Doyle |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 130 ISSN: 1651-2251 ISO Abbreviation: Acta Otolaryngol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2011-01-27 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: England |
Other Details:
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Languages: eng Pagination: 1230-6 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Children's Hospital of Pittsburgh, University of Pittsburgh, PA, USA. dswarts@pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Ear, Middle / anatomy & histology, physiology, radiography* Female Humans Male Mastoid / anatomy & histology, physiology, radiography* Medical History Taking Models, Biological* Organ Size Pressure Radiographic Image Enhancement / methods Reference Values Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P50 DC007667/DC/NIDCD NIH HHS; P50 DC007667-01A1/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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