Document Detail


Surface-active properties of Candida albicans.
MedLine Citation:
PMID:  2679378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell surface hydrophobicity may be an important factor contributing to the virulence of Candida yeast cells. Surface hydrophobic and surface polar groups would be required for a yeast cell to act as a surface-active agent. In this report, the surface activities of whole yeast cells were measured. Yeast cells added at 10(8)/ml reduced the surface tension (gamma s) of saline by 20% as determined by the du Nouy method. A 1% suspension of yeast cell wall fragments reduced gamma s of saline by 36%. Whole yeast cells caused a reduction in interfacial tension (gamma I) between hexadecane and saline. The reduction of gamma I was proportional to the surface hydrophobicity of the yeasts. Yeast cells grown in glucose as the sole carbon source (thus possessing a relatively more hydrophilic cell surface) reduced gamma I by 30%, whereas yeast cells grown in hexadecane (thus possessing a more hydrophobic cell surface) reduced gamma I by 41%. The reduction of gamma I was reversed upon the addition of a strong surfactant. It was also demonstrated that yeast cells blended with nonionic surfactants during growth in a glucose broth in order to change their cell surface hydrophobicity adhered to solid surfaces in direct proportion to their cell surface hydrophobicity. Thus, the surface-active properties of Candida yeast cells may significantly contribute to the accumulation of yeast cells at various biological interfaces such as liquid-solid, liquid-liquid, and liquid-air, leading to their eventual adhesion to solid or tissue surfaces.
Authors:
S A Klotz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  55     ISSN:  0099-2240     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-31     Completed Date:  1989-10-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2119-22     Citation Subset:  IM    
Affiliation:
Department of Medicine and Ophthalmology, Veterans Administration Medical Center, Shreveport, Louisiana 71101.
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Alkanes
Candida albicans / growth & development,  physiology*
Cell Adhesion*
Sodium Chloride
Surface Properties
Chemical
Reg. No./Substance:
0/Alkanes; 544-76-3/n-hexadecane; 7647-14-5/Sodium Chloride
Comments/Corrections

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