| Surface fragmentation of complexes from thiolate protected gold nanoparticles by ion mobility-mass spectrometry. | |
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MedLine Citation:
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PMID: 20229984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Matrix-assisted laser desorption/ionization-ion mobility-mass spectrometry (MALDI-IM-MS) was used to analyze low mass gold-thiolate fragments generated from thiolate-protected gold nanoparticles (AuNPs). This is the first report of using gas-phase structural separations by IM-MS for the characterization of AuNPs, revealing significant structural variation between organic and gold-thiolate ionic species. Through the separation of background chemical noise, gold-thiolate ion species corresponding to fragments from the AuNP surface can be isolated. In the negative ion mode, many of these fragments correlate to capping structural motifs observed in the literature. In the positive ion mode, the fragment ions do not correlate to predicted structural motifs, but are nearly identical to the positive ions generated from the gold-thiolate AuNP precursor complexes. This suggests that energetic processes during laser desorption/ionization induce a structural rearrangement in the capping gold-thiolate structure of the AuNP, resulting in the generation of positively charged gold-thiolate complexes similar to the precursors of AuNP formation by reduction and negatively charged complexes more representative of the AuNP surface. |
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Authors:
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Kellen M Harkness; Larissa S Fenn; David E Cliffel; John A McLean |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Analytical chemistry Volume: 82 ISSN: 1520-6882 ISO Abbreviation: Anal. Chem. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-06-23 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: United States |
Other Details:
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Languages: eng Pagination: 3061-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, 7330 Stevenson Center, Nashville, Tennessee 37235, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Gold
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chemistry* Metal Nanoparticles / chemistry* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods* Sulfhydryl Compounds / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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GM 076479/GM/NIGMS NIH HHS; R01 GM076479-04/GM/NIGMS NIH HHS; T32GM065086/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sulfhydryl Compounds; 7440-57-5/Gold |
| Comments/Corrections | |
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