Document Detail

Suprarenal aortic flow reduction versus angiotensin I infusion in fetal sheep.
MedLine Citation:
PMID:  2693526     Owner:  NLM     Status:  MEDLINE    
In the unanaesthetized fetal sheep, long-term suprarenal aortic blood flow reduction will cause upper body arterial blood pressure to increase. To see if the response to this procedure was entirely due to the concomitant increase in plasma renin activity, we gave an angiotensin I infusion of several days to 7 fetal sheep and compared their responses to those of 4 fetal sheep undergoing partial occlusion of the aorta above the renal arteries. Both protocols caused upper body arterial blood pressure to increase to comparable levels. Angiotensin I infusion had no effect upon venous blood pressure while suprarenal aortic blood flow reduction caused a significant increase in venous blood pressure as early as 1 day after blood flow reduction. Haematocrits were unchanged in the fetuses with flow restriction but increased in the infused fetuses. We conclude that long-term angiotensin I infusion in the fetus does not mimic the entire complex of responses to suprarenal aortic blood flow reduction.
D F Anderson; N D Binder
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  11     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1990-03-08     Completed Date:  1990-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-21     Citation Subset:  IM    
Department of Physiology, Oregon Health Sciences University, Portland 97201.
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MeSH Terms
Angiotensin I / pharmacology*
Blood Gas Analysis
Blood Pressure* / drug effects
Hypertension / physiopathology
Infusions, Intravenous
Renal Circulation* / drug effects*
Renin / metabolism
Renin-Angiotensin System / physiology*
Venous Pressure / drug effects
Grant Support
Reg. No./Substance:
9041-90-1/Angiotensin I; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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