| Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus. | |
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MedLine Citation:
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PMID: 20628017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes is a chronic disease requiring continuous medical supervision and patient education to prevent acute secondary complications. In this study, we have harnessed the inherent property of insulin to aggregate into an oligomeric intermediate on the pathway to amyloid formation, to generate a form that exhibits controlled and sustained release for extended periods. Administration of a single dose of the insulin oligomer, defined here as the supramolecular insulin assembly II (SIA-II), to experimental animals rendered diabetic by streptozotocin or alloxan, released the hormone capable of maintaining physiologic glucose levels for >120 days for bovine and >140 days for recombinant human insulin without fasting hypoglycemia. Moreover, the novel SIA-II described here not only improved the glycemic control, but also reduced the extent of secondary diabetic complications. |
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Authors:
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Sarika Gupta; Tandrika Chattopadhyay; Mahendra Pal Singh; Avadhesha Surolia |
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Publication Detail:
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Type: Journal Article Date: 2010-07-13 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-09-27 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 13246-51 Citation Subset: IM |
Affiliation:
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National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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cytology,
drug effects,
metabolism Alloxan Amyloid / chemistry, metabolism, ultrastructure Animals Blood Glucose / analysis Cattle Cells, Cultured Congo Red / chemistry Diabetes Mellitus, Experimental / blood, chemically induced, drug therapy* Diabetes Mellitus, Type 1 / blood, drug therapy* Glucose Tolerance Test Humans Hypoglycemic Agents / chemistry, therapeutic use Insulin / chemistry, metabolism, therapeutic use* Male Mice Mice, Inbred C57BL Microscopy, Atomic Force Microscopy, Electron, Transmission Protein Multimerization Rabbits Rats Rats, Wistar Spectroscopy, Fourier Transform Infrared Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 18883-66-4/Streptozocin; 50-71-5/Alloxan; 573-58-0/Congo Red |
| Comments/Corrections | |
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