Document Detail

Supramolecular domains in mixed peptide self-assembled monolayers on gold nanoparticles.
MedLine Citation:
PMID:  18698565     Owner:  NLM     Status:  MEDLINE    
Self-organization in mixed self-assembled monolayers of small molecules provides a route towards nanoparticles with complex molecular structures. Inspired by structural biology, a strategy based on chemical cross-linking is introduced to probe proximity between functional peptides embedded in a mixed self-assembled monolayer at the surface of a nanoparticle. The physical basis of the proximity measurement is a transition from intramolecular to intermolecular cross-linking as the functional peptides get closer. Experimental investigations of a binary peptide self-assembled monolayer show that this transition happens at an extremely low molar ratio of the functional versus matrix peptide. Molecular dynamics simulations of the peptide self-assembled monolayer are used to calculate the volume explored by the reactive groups. Comparison of the experimental results with a probabilistic model demonstrates that the peptides are not randomly distributed at the surface of the nanoparticle, but rather self-organize into supramolecular domains.
Laurence Duchesne; Geoff Wells; David G Fernig; Sarah A Harris; Raphaël Lévy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  9     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-02-06     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2127-34     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Cross-Linking Reagents / chemistry
Gold / chemistry*
Metal Nanoparticles / chemistry*
Molecular Sequence Data
Peptides / chemistry*,  metabolism*
Grant Support
G0200629//Medical Research Council; //Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Peptides; 7440-57-5/Gold

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