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Supraglottic Immunoglobulin-G4 related plasma cell granuloma: Case report and literature review.
MedLine Citation:
PMID:  24115385     Owner:  NLM     Status:  Publisher    
Background: Granuloma of the upper aero-digestive tract is a rare presentation of Immunoglobulin G4 (IgG4) related disease. Since the disease process was defined in 2003, only two cases affecting the laryngo-pharynx have been reported in the literature. Methods and Results: A 62 year old Caucasian male presented with persistent productive cough of brown sputum, globus symptoms, dysphagia, odynophagia, dysphonia, otalgia and general malaise over a period of two months. Investigations revealed IgG4 positive plasma cell granuloma of the supra-glottic region. This was successfully treated with oral corticosteroids. Conclusion: As IgG4 testing is not performed routinely, management recommendations have been poorly defined. The literature is reviewed and clinical characteristics, pathology, diagnosis and management are discussed. The authors theorise that IgG4 related disease involving the larynx and pharynx may be more common than suggested by the paucity of reported cases. Head Neck, 2013.
Jeremy F Khoo; Michael Batt; Paul Stimpson; Adnan Safdar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-30
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.
Department of Otolaryngology, Monash Health, Melbourne, Victoria, Australia.
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