Document Detail

Suprachiasmatic nucleus: Cellular clocks and networks.
MedLine Citation:
PMID:  22877663     Owner:  NLM     Status:  In-Data-Review    
The suprachiasmatic nucleus (SCN), the master circadian clock of mammals, is composed of multiple circadian oscillator neurons. Most of them exhibit significant circadian rhythms in their clock gene expression and spontaneous firing when cultured in dispersed cells, as well as in an organotypic slice. The distribution of periods depends on the SCN tissue organization, suggesting that cell-to-cell interaction is important for synchronization of the constituent oscillator cells. This cell-to-cell interaction involves both synaptic interactions and humoral mediators. Cellular oscillators form at least three separate but mutually coupled regional pacemakers, and two of them are involved in the photoperiodic regulation of behavioral rhythms in mice. Coupling of cellular oscillators in the SCN tissue compensates for the dysfunction due to clock gene mutations, on the one hand, and desynchronization within and between the regional pacemakers that suppresses the coherent rhythm expression from the SCN, on the other hand. The multioscillator pacemaker structure of the SCN is advantageous for responding to a wide range of environmental challenges without losing coherent rhythm outputs.
Sato Honma; Daisuke Ono; Yohko Suzuki; Natsuko Inagaki; Tomoko Yoshikawa; Wataru Nakamura; Ken-Ichi Honma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in brain research     Volume:  199     ISSN:  1875-7855     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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