Document Detail

Suppressor resident peritoneal macrophages and peritonitis incidence in continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  2946966     Owner:  NLM     Status:  MEDLINE    
Our study was designed to see if peritoneal macrophages (PM) of continuous ambulatory peritoneal dialysis (CAPD) uremic patients, by weakening local defense, could contribute to an increase of peritonitis incidence. Coincubation of nonadherent control responding cells (NACRC) and PM from normal subjects or CAPD patients with low peritonitis incidence (LPI) did not modify blastogenic response of cells to PHA. Coincubation of NACRC and PM from CAPD patients with high peritonitis incidence (HPI) produced noticeable decrease in blastogenic response; these PM, unable to produce normal amounts of Interleukin-1 (IL-1), released large amounts of prostaglandin E2 (PGE2). CAPD patients with LPI and normal subjects produced both substances in similar amounts. PM of CAPD patients with HPI were less able to kill bacteria than those from normal subjects and CAPD patients with LPI, showing a stronger suppressor effect on local defense. This suppressor activity correlated directly to PGE2 release and inversely to IL-1 production. We can hypothesize that in some uremic patients, subpopulations of macrophages growing in response to local stimuli produce humoral substances, negatively affecting cellular-mediated defense and favoring elevated bacterial expansion in peritoneum.
S Lamperi; S Carozzi
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  44     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-31     Completed Date:  1986-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
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MeSH Terms
Interleukin-1 / analysis
Lymphocyte Activation*
Macrophages / immunology*
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory* / adverse effects
Peritonitis / etiology*
Prostaglandins E / analysis
Reference Values
Staphylococcus epidermidis / immunology
T-Lymphocytes, Regulatory / immunology*
Uremia / immunology,  therapy
Reg. No./Substance:
0/Interleukin-1; 0/Prostaglandins E; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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