| Suppressor of cytokine signaling proteins as regulators of innate immune signaling. | |
| | |
MedLine Citation:
|
PMID: 22201825 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The innate immune system builds up the body's first line of defense against invading pathogenic microorganisms. For effective defense of pathogenic invaders, a structured inflammatory reaction has to be initiated that is strongly dependent on cell-to-cell communication. Inflammation in turn is a potentially autodestructive reaction that is tightly controlled to balance antimicrobial activity and host damage. Suppressor of cytokine signaling (SOCS) proteins have been identified as crucial negative regulators of various hematopoietic cytokines employing Janus kinas (JAK) and signal transducer and activator of transcription (STAT) signaling. Further results now imply that also signaling by pattern recognition receptors (PRR) of the innate immune system that use a distinct signaling cascade induce and get regulated by SOCS proteins. Thus, SOCS proteins not only modulate cell communication through JAK/STAT dependent cytokines but also regulate signaling by pattern recognition receptors including the Toll-like receptors (TLRs). A model is presented that integrates the current, partly conflicting, data on the role of SOCS proteins in innate immunity's NFkappaB signaling. |
| | |
Authors:
|
Julia Strebovsky; Patrick Walker; Alexander H Dalpke |
Related Documents
:
|
16036795 - Up-regulation of astrocyte cyclooxygenase-2, ccaat/enhancer-binding protein-homology pr... 17667525 - Rofecoxib has different effects on chemokine production in colorectal cancer cells and ... 687875 - Prostaglandin production by macrophages and the effect of anti-inflammatory drugs. 9203975 - Enhancement of b-cell translocation gene-1 expression by prostaglandin e2 in macrophage... 15857805 - Limited in vivo reactivity of polyclonal effector cytotoxic t cells towards altered pep... 2508445 - The phosphatidylinositol response of chondrocytes in culture. |
Publication Detail:
|
Type: Journal Article Date: 2012-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience : a journal and virtual library Volume: 17 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 1627-39 Citation Subset: IM |
Affiliation:
|
Dept. of Infectious Diseases - Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Permeation and gating mechanisms in store-operated CRAC channels.
Next Document: The role of diet in gastric cancer: still an open question.