Document Detail


Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus.
MedLine Citation:
PMID:  20064913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the aim of investigating the role of suppressor of cytokine signaling 1 (SOCS1) in the pathogenesis of systemic lupus erythematosus, 107 patients with systemic lupus erythematosus, 101 healthy controls, and 151 patients with ankylosing spondylitis were enrolled in this study. SOCS1 mRNA level was measured by the method of quantitative real-time polymerase chain reaction. SOCS1 polymorphisms were detected by the polymerase chain reaction/restriction fragment length polymorphisms method. Systemic lupus erythematosus disease activity was evaluated with the SLEDAI. This study showed that the SOCS1 mRNA expression was significantly higher in the patients with systemic lupus erythematosus than in the healthy controls (p = 0.0014). Patients with active systemic lupus erythematosus had a higher expression of SOCS1 mRNA than the patients with inactive systemic lupus erythematosus (p = 0.035). There was no significant difference in the frequencies of the SOCS1-1478CA/del polymorphisms among the patients with systemic lupus erythematosus, healthy controls, and patients with ankylosing spondylitis. The genotype frequency of the SOCS1-1478 polymorphisms in the dominant model (CA/del+del/del versus CA/CA) was significantly decreased in the patients with thrombocytopenia compared with those without thrombocytopenia (p(c) = 0.035). Moreover, the allele frequency of SOCS1-1478del was also significantly lower in the patients with thrombocytopenia than in those without thrombocytopenia (p( c) = 0.02). In conclusion, this study demonstrated that the expression of SOCS1 mRNA was significantly increased in patients with systemic lupus erythematosus. Moreover, SOCS1 mRNA levels in patients with active systemic lupus erythematosus were significantly higher than those in the inactive patients. We also found that the systemic lupus erythematosus patients with thrombocytopenia have a lower frequency of SOCS1-1478del compared with patients without thrombocytopenia.
Authors:
H C Chan; L Y Ke; L L Chang; C C Liu; Y H Hung; C H Lin; R N Li; W C Tsai; H W Liu; J H Yen
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Publication Detail:
Type:  Journal Article     Date:  2010-01-11
Journal Detail:
Title:  Lupus     Volume:  19     ISSN:  1477-0962     ISO Abbreviation:  Lupus     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-08-25     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  696-702     Citation Subset:  IM    
Affiliation:
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Female
Gene Expression*
Genetic Predisposition to Disease
Genotype
Humans
Lupus Erythematosus, Systemic / genetics*,  physiopathology
Male
Middle Aged
Polymorphism, Genetic*
RNA, Messenger / genetics,  metabolism
Suppressor of Cytokine Signaling Proteins / genetics*,  metabolism
Young Adult
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/SOCS1 protein, human; 0/Suppressor of Cytokine Signaling Proteins

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