| Suppressor cell activity in patients with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 6454336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-one patients with definite or classical rheumatoid arthritis (RA) were investigated for their suppressor cell activity by a Concanavalin A suppressor cell assay. Two patients had active disease, 9 moderately active disease, and 10 inactive disease according to clinical and laboratory parameters. A mean of 41 +/- 7% suppression was observed in RA patients as compared to 63 +/- 7% suppression observed in 10 healthy age and sex matched controls. No significant difference was observed between patients with moderately active or active disease (39 +/- 9%) and patients with inactive RA (43 +/- 10%). However, a borderline statistical significance (p = 0.05) was seen between controls and patients with moderately active or active RA. Use of autologous serum instead of AB serum for suppressor cell induction had no significant effect, although an increase of the mean suppression was noted (58 +/- 6%) in patient's group. No correlations existed between suppressor cell activity and presence of circulating Clq-binding immune complexes (solid-phase Clq assay), rheumatoid factor (Waaler-Rose test) or antinuclear antibodies (indirect immunofluorescence). This study indicates that lymphocytes of patients with inactive RA exert normal suppressor cell activity. It may well be that patients with active rheumatoid arthritis have decreased suppressor cell function. This will be assessed in a larger group of patients with active disease. |
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Authors:
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J S Smolen; G Lanzer; O Scherak; E J Menzel; C Steffen; W Knapp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions. Supplements Volume: 7 ISSN: 0379-0363 ISO Abbreviation: Agents Actions Suppl. Publication Date: 1980 |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801014 Medline TA: Agents Actions Suppl Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 204-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Antinuclear Antigen-Antibody Complex Arthritis, Rheumatoid / immunology* Female Humans Male Middle Aged Rheumatoid Factor / immunology T-Lymphocytes, Regulatory / immunology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Antigen-Antibody Complex; 9009-79-4/Rheumatoid Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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