| Suppressive therapy of thyroid nodules in patients with previous radiotherapy to the head and neck. | |
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MedLine Citation:
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PMID: 3177753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This is a prospective, randomized study of 431 patients with palpable thyroid nodules who had previous radiotherapy for benign disorders of the head and neck area to determine the response of the thyroid nodules to suppressive therapy and the incidence of thyroid cancer in patients who could not be suppressed and had surgery. A complete response was achieved within 6 months in 18.3 percent of the patients, and in an additional 26 percent of patients between 7 and 12 months postoperatively. Twenty percent of the patients showed complete disappearance of nodules after 1 to 2 years of suppressive therapy. Twenty-two percent who underwent surgery showed carcinoma. If suppressive therapy is to be used, a trial of 1 year rather than 3 or 6 months, as often recommended, may be appropriate. |
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Authors:
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M S Razack; K Shimaoka; K Sako; U Rao |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of surgery Volume: 156 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-11-15 Completed Date: 1988-11-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 290-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Head and Neck Surgery and Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Double-Blind Method Female Head and Neck Neoplasms / radiotherapy* Humans Male Middle Aged Neoplasms, Radiation-Induced / drug therapy, surgery, therapy* Prospective Studies Random Allocation Thyroid Diseases / drug therapy, surgery, therapy* Thyroid Extract, Desiccated / therapeutic use Thyroid Neoplasms / drug therapy, surgery, therapy* Thyroidectomy Triiodothyronine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Extract, Desiccated; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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