Document Detail

Suppressive effect of sera from patients undergoing chronic hemodialysis on neutrophil chemiluminescence response.
MedLine Citation:
PMID:  8210566     Owner:  NLM     Status:  MEDLINE    
To determine the mechanism of easy infectability of uremic patients, we studied the effect of sera from uremic patients who were undergoing chronic hemodialysis on the chemiluminescence (CL) response of polymorphonuclear leukocytes (PMN). The luminol-dependent CL response was examined following stimulation with phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (FMLP). The patient's sera suppressed the CL response following stimulation by PMA, but not by FMLP. These findings suggest that sera from uremic patients undergoing hemodialysis contain a suppressive substance that suppresses the activation of PMNs by PMA.
T Matsumoto; S Kubo; K Takahashi; M Haraoka; M Tanaka; J Kumazawa; K Yoshimine; T Fukumitsu; Y Mihara; K Takayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  15     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-18     Completed Date:  1993-11-18     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-32     Citation Subset:  IM    
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Chemiluminescent Measurements
Lymphocyte Activation
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / drug effects,  physiology*
Renal Dialysis*
Respiratory Burst / physiology
Tetradecanoylphorbol Acetate / pharmacology
Uremia / blood*,  therapy
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine

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