| Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis. | |
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MedLine Citation:
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PMID: 22564173 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The anti-inflammatory effect of berberine was evaluated in murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Berberine, given orally at 40, 20, 10 mg/kg for 10 days, ameliorated all the supposed inflammatory symptoms of the induced colitis, such as body weightloss, blood hemoglobin reduction, high myeloperoxidase levels, and malondialdehyde content-inflamed mucosa. Furthermore, the cytokine production of splenic lymphocytes was analyzed. The results showed the IFN-γ and IL-12 were increased, but IL-4 and IL-10 were decreased in DSS-induced colitis,when those were compared with the normal control. But the administration of berberine to DSS-induced colitis mice showed lower production of IFN-γ and IL-12 and higher production of IL-4 and IL-10 than the DSS-induced colitis mice. The results suggest that the protective effects of berberine against the DSS-induced colitis may be associated with the regulation of cytokine production. |
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Authors:
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Tie Hong; Zhen Yang; Chuan-Feng Lv; Yu Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: 34 ISSN: 1532-2513 ISO Abbreviation: Immunopharmacol Immunotoxicol Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 391-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Pharmacy, Jilin University , Changchun 130021 , P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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