| Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas. | |
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MedLine Citation:
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PMID: 21367957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation contributes to the development of papillomas and squamous cell carcinomas in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-l3-acetate (TPA) model of skin carcinogenesis. Synthetic oligonucleotides (ODN) containing repetitive TTAGGG motifs have been shown to block deleterious inflammatory reactions in murine models of autoimmunity, pneumonitis, and shock. This article examines whether treatment with suppressive (Sup) ODN can interfere with DMBA/TPA-induced inflammation, thereby reducing papilloma formation. Results indicate that Sup ODN block TPA-dependent skin hyperplasia, edema, and leukocytic infiltration. Sup ODN also inhibit the upregulation of genes encoding pro-oncogenic chemokines and other markers of inflammation including CXCL2, CCL2, COX-2, and ODC (ornithine decarboxylase). Of greatest import, Sup ODN reduce papilloma formation in a dose- and sequence-dependent manner. These findings suggest that Sup ODN may provide a novel means of preventing inflammation and associated oncogenesis. |
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Authors:
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Hidekazu Ikeuchi; Takeshi Kinjo; Dennis M Klinman |
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Publication Detail:
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Type: Journal Article Date: 2011-03-02 |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: 4 ISSN: 1940-6215 ISO Abbreviation: Cancer Prev Res (Phila) Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-05 Completed Date: 2011-09-27 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 752-7 Citation Subset: IM |
Affiliation:
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Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene
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toxicity Animals Chemokine CCL2 / genetics, metabolism Chemokine CXCL2 / genetics, metabolism Cyclooxygenase 2 / genetics, metabolism Female Inflammation / chemically induced, genetics, prevention & control* Mice Oligodeoxyribonucleotides / therapeutic use* Ornithine Decarboxylase / genetics, metabolism Papilloma / chemically induced, genetics, prevention & control* RNA, Messenger / genetics Reverse Transcriptase Polymerase Chain Reaction Skin Neoplasms / chemically induced, genetics, prevention & control* Tetradecanoylphorbol Acetate / toxicity |
| Grant Support | |
ID/Acronym/Agency:
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ZIA BC010853-04/BC/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL2; 0/Chemokine CXCL2; 0/Oligodeoxyribonucleotides; 0/RNA, Messenger; 16561-29-8/Tetradecanoylphorbol Acetate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; EC 1.14.99.-/Ptgs2 protein, mouse; EC 1.14.99.1/Cyclooxygenase 2; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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