Document Detail

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats.
MedLine Citation:
PMID:  22790930     Owner:  NLM     Status:  In-Data-Review    
We have recently reported that oral gavage of a potato extract (Potein<sup>®</sup>) suppressed the food intake in rats. The satiating effect of the potato extract was compared in the present study to other protein sources, and the involvement of endogenous cholecystokinin (CCK) secretion was examined. Food consumption was measured in 18-h fasted rats after oral gavage of the potato extract or other protein sources. The CCK-releasing activity of the potato extract was then examined in anesthetized rats with a portal cannula. Oral gavage of the potato extract reduced the food intake in the rats, the effect being greater than with casein and a soybean β-conglycinin hydrolysate. The suppressive effect on appetite of the potato extract was attenuated by treating with a CCK-receptor antagonist (devazepide). The portal CCK concentration was increased after a duodenal administration of the potato extract to anesthetized rats. These results indicate that the potato extract suppressed the food intake in rats through CCK secretion.
Wenya Chen; Tohru Hira; Shingo Nakajima; Hiroshi Tomozawa; Masahito Tsubata; Kazuya Yamaguchi; Hiroshi Hara
Publication Detail:
Type:  Journal Article     Date:  2012-06-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  76     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1104-9     Citation Subset:  IM    
Division of Applied Biosciences, Graduate School of Agriculture, Hokkaido University.
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