| Suppression of thyrotropin by 3,5-dimethyl-3'-isopropyl-L-thyronine in euthyroid and hypothyroid rats. | |
| | |
MedLine Citation:
|
PMID: 7408758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) a nonhalogenated thyroid hormone analog, on plasma and pituitary TSH levels was studied in euthyroid and 5-day-thyroidectomized (T-5d) rats. The minimal dose of DIMIT which suppressed basal plasma TSH for a 24-h period was 5.3 micrograms/100 g BW in the euthyroid rats and 5.2 micrograms/100 g BW in the T-5d group. The equipotent doses of T3 were 1.0 and 1.5 micrograms/100 g BW, respectively. Thus, the apparent DIMIT to T3 molar ratio ranged from 6.6 in the hypothyroid to 10 in the euthyroid group. The suppression of TRH-induced TSH release in the euthyroid rats required a high dose of DIMIT (9.2 micrograms/100 g BW), resulting in a DIMIT to T3 molar ratio of 17. Time-course studies comparing the effects of equipotent doses of DIMIT and T3 on TSH release rates in euthyroid and T-5d rats have shown a maximal suppression by 3--24 h after the administration of both T3 and DIMIT. However, the recovery from the effect was slower after T3. TSH synthesis in the T-5d group was similarly suppressed by DIMIT and T3. DIMIT has significant thyromimetic activity in euthyroid and hypothyroid rats, as evidenced by the suppresion of TSH synthesis and release. |
| | |
Authors:
|
S Melmed; O Spira; A Gordon; J Gross; E C Jorgensen; J M Hershman |
Related Documents
:
|
17196228 - Physical training in developing rats does not influence the kindling development in the... 19730878 - Endurance training accelerates exhaustive exercise-induced mitochondrial dna deletion a... 19900418 - Exercise exerts neuroprotective effects on parkinson's disease model of rats. 19821018 - Effect of exercise on learning and memory in a rat model of developmental stress. 8501748 - An imaginative approach to synovitis--the role of hypoxic reperfusion damage in arthritis. 19122058 - Evaluations of labrador retrievers with exercise-induced collapse, including response t... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Endocrinology Volume: 107 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1980 Oct |
Date Detail:
|
Created Date: 1980-11-24 Completed Date: 1980-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1050-4 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dose-Response Relationship, Drug Hypothyroidism / metabolism* Male Pituitary Gland / drug effects, metabolism* Rats Thyroid Gland / physiology* Thyronines / pharmacology* Thyrotropin / metabolism* Thyroxine / blood Triiodothyronine / blood |
| Grant Support | |
ID/Acronym/Agency:
|
HD-7181/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Thyronines; 26384-44-1/3,5-dimethyl-3'-isopropyl-L-thyronine; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of 17 beta-estradiol on collagen and noncollagenous protein synthesis in the uterus and s...
Next Document: Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siverian (Phodopus ...