Document Detail

Suppression of threatened premature labor by administration of cortisol and 17 alpha-hydroxyprogesterone caproate: a comparison with ritodrine.
MedLine Citation:
PMID:  7424996     Owner:  NLM     Status:  MEDLINE    
A shift in progesterone-to-estradiol balance to estradiol dominance is assumed to be a prerequisite for regular uterine contractions. To antagonize this effect in premature labor 24 consecutive women were treated with intravenous cortisol for 3 days and with weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17 OHP-C). Twenty-four similar patients treated with ritodrine served as a reference group. The delivery was postponed by at least 1 week in 21 patients (87.5%) in the steroid treatment group and in 18 patients (75%) in the ritodrine group. The premature labor lasted for 5.1 +/- 0.4 hours (mean +/- SEM) with steroid therapy and for 2.2 +/- 0.3 hours with ritodrine. In singleton pregnancies the gestational length and birth weight of the newborn infants were greater in the steroid treatment group (N = 23, 39.1 +/- 0.3 weeks, 3,460 +/- 119 gm) than in the ritodrine group (N = 24, 37.7 +/- 0.4 weeks, 3,106 +/- 118 gm). Steroid treatment suppressed serum estradiol concentrations (maximally by 60%) and, to a lesser extent, testosterone, estriol, and progresterone levels (maximally by 30%).
A Kauppila; A L Hartikainen-Sorri; O Jänne; R Tuimala; P A Järvinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  138     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  404-8     Citation Subset:  AIM; IM    
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MeSH Terms
Estradiol / blood
Estradiol Antagonists / therapeutic use*
Estriol / blood
Hydrocortisone / therapeutic use*
Hydroxyprogesterones / therapeutic use*
Obstetric Labor, Premature / prevention & control*
Progesterone / blood
Propanolamines / therapeutic use*
Ritodrine / therapeutic use*
Testosterone / blood
Reg. No./Substance:
0/Estradiol Antagonists; 0/Hydroxyprogesterones; 0/Propanolamines; 26652-09-5/Ritodrine; 50-23-7/Hydrocortisone; 50-27-1/Estriol; 50-28-2/Estradiol; 57-83-0/Progesterone; 58-22-0/Testosterone; 630-56-8/17-alpha-hydroxy-progesterone caproate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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