Document Detail


Suppression of spontaneous development of uterine adenomyosis by a Chinese herbal medicine, keishi-bukuryo-gan, in mice.
MedLine Citation:
PMID:  8372144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Keishi-bukuryo-gan (KBG) is a traditional Chinese herbal remedy and has been used for the treatment of gynecological disorders, such as hypermenorrhea, dysmenorrhea, and infertility. The effects of KBG on the development of uterine adenomyosis, which is characterized by an abnormal growth of glands and stroma into and beyond the smooth muscle layers of the uterus, were examined in an experimental animal model using the SHN strain of mice. Mice fed handmade chow containing relatively high doses of KBG (0.5% and 1%) showed a significantly lower incidence of adenomyosis and lower activity of thymidylate synthetase (TS) in the uteri than mice fed control handmade chow containing no KBG. The long-term exposure to KBG between 25 and 120 days of age hardly affected the estrous cycle, food intake and body weight. However, mice provided with chow containing a low dose of KBG (0.1%) showed no difference in the incidence of adenomyosis as compared with the controls. The inhibitory effects of the high doses of KBG were nullified by pituitary isografting, which has been proved to enhance the development of adenomyosis. The present mouse data support the view in humans that the oral administration of KBG is a useful tool for the treatment of uterine adenomyosis.
Authors:
T Mori; S Sakamoto; T Singtripop; M K Park; T Kato; S Kawashima; H Nagasawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  59     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-10-08     Completed Date:  1993-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  308-11     Citation Subset:  IM    
Affiliation:
Zoological Institute, Faculty of Science, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / pharmacology*
Drugs, Chinese Herbal / pharmacology*
Endometriosis / enzymology,  prevention & control*
Female
Mice
Ovarian Neoplasms / enzymology,  prevention & control*
Thymidine Kinase / metabolism
Thymidylate Synthase / metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/keishibukuryogan; EC 2.1.1.45/Thymidylate Synthase; EC 2.7.1.21/Thymidine Kinase

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