Document Detail

Suppression of spontaneous breathing during high-frequency jet ventilation. Separate effects of lung volume and jet frequency.
MedLine Citation:
PMID:  3116059     Owner:  NLM     Status:  MEDLINE    
The effect of ventilatory frequency of high-frequency jet ventilation (HFJV) from 1 to 5 Hz, apart from changes in thoracic volume, on spontaneous breathing activity was studied in Yorkshire piglets under pentobarbital anesthesia. The highest PaCO2 at which the animals did not breathe against the ventilator (apnea point) was established either by changing minute volume of ventilation or by adding CO2 to the respiratory gas. The higher the apnea point, the higher the suppression of spontaneous breathing activity was assumed to be. If the apnea point was searched for by changing minute volume a progressive increase of suppression of spontaneous respiratory activity was found at ventilatory rates of 3 Hz or more, concomitantly with a rise in end-expiratory pressure (PEE). In case the tidal volume was kept constant, increase of ventilatory rate resulted in a tremendous increase of lung volume, together with considerably higher levels of PEE. When under these conditions the apnea point was searched for by adding CO2 to the respiratory gas a much higher CO2-drive was needed for spontaneous breathing and therefore a much stronger inhibition of spontaneous breathing was concluded. By placing the animals in a body box in which pressure could be varied, thoracic volume could be kept constant during HFJV. When thoracic volume was kept constant in this way a constant tidal volume at increasing jet frequencies resulted in only a slight increase in suppression of spontaneous breathing. We conclude that the increase in lung volume is a major factor in suppressing central respiratory activity during HFJV. Jet frequency by itself might be an additional suppressive factor.(ABSTRACT TRUNCATED AT 250 WORDS)
A J van Vught; A Versprille; J R Jansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  13     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-27     Completed Date:  1987-10-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-22     Citation Subset:  IM    
Department of Pulmonary Diseases, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Apnea / physiopathology
Carbon Dioxide / physiology
High-Frequency Jet Ventilation*
Lung Volume Measurements
Reg. No./Substance:
124-38-9/Carbon Dioxide

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