Document Detail

Suppression of recurrent transient ischemic attacks by a statin agent.
MedLine Citation:
PMID:  11222801     Owner:  NLM     Status:  MEDLINE    
Recent studies of hydroxy-methylglutaryl coenzyme A reductase inhibitors have demonstrated that therapy with statins is associated with a significant decrease in the risk of stroke and TIA in patients with coronary artery disease. The underlying mechanism responsible for this effect is unclear. The author presents two patients who had cessation of TIAs upon institution of statin therapy. A variety of non-lipid-lowering mechanisms may account for this beneficial effect. This initial observation, if confirmed by further study, may suggest a role for statin agents in preventing recurrent TIAs.
M J Alberts
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  56     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-2     Citation Subset:  AIM; IM    
Stroke Acute Care Unit, Duke University Medical Center, Durham, NC, USA.
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MeSH Terms
Anticholesteremic Agents / therapeutic use*
Ischemic Attack, Transient / drug therapy*,  physiopathology*
Middle Aged
Pravastatin / therapeutic use*
Stroke / prevention & control
Reg. No./Substance:
0/Anticholesteremic Agents; 81093-37-0/Pravastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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