| Suppression of plasma endothelin-1 level by alpha-human atrial natriuretic peptide and angiotensin converting enzyme inhibition in normal men. | |
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MedLine Citation:
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PMID: 8366764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) on plasma endothelin-1 (ET-1) level was examined in 6 healthy subjects. Intravenous infusion of alpha-ANP (0.1 micrograms/kg/min) resulted in significant falls in plasma renin activity and aldosterone, but without effect on ET-1 level. An angiotensin converting enzyme inhibitor, captopril, increased plasma renin activity and decreased aldosterone, respectively. However, plasma ET-1 levels were not modified by captopril. In cases with alpha-hANP infusion after captopril (25 mg, p.o.,), the renin-angiotensin-aldosterone system was further inhibited compared with the first group, and ET-1 at 60 min was significantly suppressed from the baseline. These data suggest that alpha-hANP when combined with captopril brings about the suppression of plasma ET-1 concentrations in men. |
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Authors:
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J Uemasu; H Matsumoto; M Kitano; H Kawasaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 53 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-10-01 Completed Date: 1993-10-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 969-74 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Atrial Natriuretic Factor / pharmacology* Blood Pressure / drug effects Captopril / pharmacology* Diuresis Endothelins / blood* Heart Rate / drug effects Humans Male Reference Values Renin / blood Serum Albumin / analysis Sodium / urine |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Serum Albumin; 52-39-1/Aldosterone; 62571-86-2/Captopril; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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