Document Detail

Suppression of pentylenetetrazol-elicited seizure activity by intraosseous lorazepam in pigs.
MedLine Citation:
PMID:  2752999     Owner:  NLM     Status:  MEDLINE    
Use of the intraosseous (i.o.) route as an alternative venous access for drug administration has increased. This study examined the efficacy of i.o. lorazepam (LZP) in suppressing pentylenetetrazol (PTZ)-induced seizure activity in pigs. Domestic swine (13-20 kg) were prepared for recordings of arterial blood pressure, EEG, and electrocortical activity. Seizure activity was induced by PTZ (100 mg/kg i.v.). Sixty seconds after onset of seizure activity, animals either received no drug (control) or LZP (1.0 mg/kg) administered i.v. or i.o. via an 18- or 13-gauge spinal needle inserted in the right proximal tibia. Both i.o. and i.v. LZP significantly suppressed the duration of seizure activity (DSA) (s/min interval) within 1 min following drug administration: DSA control, 46.2 +/- 3.6; i.v. LZP, 25.0 +/- 5.1; i.o. (18-gauge) LZP, 27.6 +/- 6.0; i.o. (13-gauge) LZP, 24.0 +/- 2.4. Seizure activity was essentially abolished at 1 min following LZP infusion. In addition, both i.v. and i.o. LZP did not have significant effects on the basal heart rate and mean arterial blood pressure. The data demonstrate that in swine (1) the i.o. route is an effective alternative venous access for LZP administration, and (2) the size of spinal needles does not affect the antiepileptic efficacy of i.o. infusion of LZP.
K F Jim; C M Lathers; V L Farris; L F Pratt; W H Spivey
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  30     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  480-6     Citation Subset:  IM    
Department of Pharmacology, Medical College of Pennsylvania, Philadelphia.
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MeSH Terms
Blood Pressure / drug effects
Bone and Bones
Heart Rate / drug effects
Infusions, Intravenous
Infusions, Parenteral
Lorazepam / administration & dosage*,  pharmacology
Status Epilepticus / chemically induced,  drug therapy*
Time Factors
Reg. No./Substance:
54-95-5/Pentylenetetrazole; 846-49-1/Lorazepam

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