| Suppression of palmoplantar pustulosis symptoms with oral 8-methoxypsoralen and high-intensity UVA irradiation. | |
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MedLine Citation:
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PMID: 6653854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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9 patients with long-standing palmoplantar pustulosis were treated with oral 8-methoxypsoralen and high-intensity UVA irradiation (PUVA, 46.2 mW/cm2). 20 irradiations with single doses of up to 14.8 J/cm2 resulted in good or excellent clearing in 4 out of 5 patients, while none of 4 patients receiving 5-6 irradiations of up to 5.2 J/cm2 improved significantly. Comparison with earlier investigations leads to the conclusion that systemic PUVA is more efficient than topical PUVA in the treatment of palmoplantar pustulosis. This may result from different skin distribution of psoralen or from a more rapid decline in the photosensitivity of topically medicated skin during prolonged irradiation as compared to skin sensitized by oral psoralen administration. The use of a high-irradiance UVA source diminishes the influence of this time factor and improves patient compliance. |
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Authors:
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R Paul; C T Jansén |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Dermatologica Volume: 167 ISSN: 0011-9075 ISO Abbreviation: Dermatologica Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0211607 Medline TA: Dermatologica Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 283-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Female Foot Dermatoses / drug therapy* Hand Dermatoses / drug therapy* Humans Male Methoxsalen / administration & dosage* Middle Aged PUVA Therapy* Photochemotherapy* Suppuration |
| Chemical | |
Reg. No./Substance:
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298-81-7/Methoxsalen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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