Document Detail


Suppression of norepinephrine-induced thermogenesis in human obesity by diet and weight loss.
MedLine Citation:
PMID:  4030198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The response of metabolic rate to norepinephrine infusion was studied in seven obese subjects before and after large amounts of weight loss. Resting metabolic rate fell from a mean of 2254 kcal (9.4 MJ) to 1682 kcal (7.0 MJ) per 24 h. The thermic response to norepinephrine infusion was reduced by 50 percent from 7527 (31.5 MJ) to 3369 (14.0 MJ) kcal/24 h/T0-45 following weight loss and on continued diet. This adaptation to weight loss could contribute to the diminished rate of weight loss that occurs with continued dieting. Previous contradictory findings of normal and reduced norepinephrine-induced thermogenesis in human obesity could result from subjects being studied under different dietary conditions.
Authors:
N Finer; P C Swan; F T Mitchell
Related Documents :
16446688 - Body weight satisfaction and weight loss attempts in fitness activity involved women.
11175968 - Variation in lipid levels in morbidly obese patients operated with the lap-band adjusta...
16238868 - Early treatment response as a predictor of ongoing weight loss in obesity treatment.
15282028 - "a calorie is a calorie" violates the second law of thermodynamics.
6930928 - In vitro effects of lecithin:cholesterol acyltransferase on apolipoprotein distribution...
10099428 - Effect of post-induction nutrient feeding strategies on the production of bioadhesive p...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity     Volume:  9     ISSN:  -     ISO Abbreviation:  Int J Obes     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-21     Completed Date:  1985-10-21     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7703240     Medline TA:  Int J Obes     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Body Temperature Regulation* / drug effects
Body Weight*
Diet, Reducing*
Energy Metabolism
Female
Humans
Male
Middle Aged
Norepinephrine / pharmacology*
Obesity / metabolism*
Chemical
Reg. No./Substance:
X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Therapeutic doses of phenylpropanolamine increase supine systolic blood pressure.
Next Document:  Quetelet's index (W/H2) as a measure of fatness.