Document Detail

Suppression of natural killer cells after acute intoxication with alcohols and cholinotropic preparations and their reactivation with T-activin.
MedLine Citation:
PMID:  12717515     Owner:  NLM     Status:  MEDLINE    
Acute poisoning with alcohols and cholinotropic preparations carboxyphosphamide and atropine (0.8 LD(50)) was modeled on male outbred mice weighing 18-24 g. The decrease in activity of natural killer cells was most pronounced after injection of atropine, but insignificant after treatment with ethanol. The inhibitory effect of ethylene glycol, methanol, and methanol on functional activity of natural killer cells in vitro directly depended on their concentration. The effects of alcohols in equimolar concentrations of 10, 100, and 500 mM were similar. Therefore, immunotoxicity of alcohols was associated with the action of their metabolites. The ability of products formed after biotransformation of ethylene glycol, methanol, and ethanol in equimolar concentrations to cause damage to natural killer cells decreased in the following order: glyoxylic acid>formic acid>acetaldehyde>glycolaldehyde>glycolic acid. T-Activin injected subcutaneously in doses of 2.5 and 5.0 microg/kg for 3 days normalized activity of natural killer cells suppressed after acute poisoning with alcohols and cholinotropic preparations.
P F Zabrodskii; V F Kirichuk; V G Germanchuk; M L Nodel'; M L Rush; A O Molotkov; G M Mal'tseva; O V Osipov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-04-28     Completed Date:  2004-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-61     Citation Subset:  IM    
Saratov State Medical University.
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MeSH Terms
Acute Disease
Alcoholic Intoxication / immunology*
Killer Cells, Natural / drug effects*,  immunology
Organosilicon Compounds / poisoning*
Peptides / pharmacology*
Thymus Extracts / pharmacology*
Reg. No./Substance:
0/Organosilicon Compounds; 0/Peptides; 0/Thymus Extracts; 89492-35-3/T-activin

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