| Suppression of natural killer cells after acute intoxication with alcohols and cholinotropic preparations and their reactivation with T-activin. | |
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MedLine Citation:
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PMID: 12717515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute poisoning with alcohols and cholinotropic preparations carboxyphosphamide and atropine (0.8 LD(50)) was modeled on male outbred mice weighing 18-24 g. The decrease in activity of natural killer cells was most pronounced after injection of atropine, but insignificant after treatment with ethanol. The inhibitory effect of ethylene glycol, methanol, and methanol on functional activity of natural killer cells in vitro directly depended on their concentration. The effects of alcohols in equimolar concentrations of 10, 100, and 500 mM were similar. Therefore, immunotoxicity of alcohols was associated with the action of their metabolites. The ability of products formed after biotransformation of ethylene glycol, methanol, and ethanol in equimolar concentrations to cause damage to natural killer cells decreased in the following order: glyoxylic acid>formic acid>acetaldehyde>glycolaldehyde>glycolic acid. T-Activin injected subcutaneously in doses of 2.5 and 5.0 microg/kg for 3 days normalized activity of natural killer cells suppressed after acute poisoning with alcohols and cholinotropic preparations. |
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Authors:
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P F Zabrodskii; V F Kirichuk; V G Germanchuk; M L Nodel'; M L Rush; A O Molotkov; G M Mal'tseva; O V Osipov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 135 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-04-28 Completed Date: 2004-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 59-61 Citation Subset: IM |
Affiliation:
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Saratov State Medical University. pz@renet.com.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Alcoholic Intoxication / immunology* Animals Killer Cells, Natural / drug effects*, immunology Male Mice Organosilicon Compounds / poisoning* Peptides / pharmacology* Thymus Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Organosilicon Compounds; 0/Peptides; 0/Thymus Extracts; 89492-35-3/T-activin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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