| Suppression of nasopharyngeal carcinoma cell by targeting β-catenin signaling pathway. | |
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MedLine Citation:
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PMID: 22142772 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To investigate the role of β-catenin in pathogenesis of nasopharyngeal carcinoma (NPC). Methods: Cellular proliferation, apoptosis, matrix penetration assay, and western blotting were employed to determine cell biological changes in NPC cell lines transfected with β-catenin siRNA. Immunohistochemistry staining was used to detect β-catenin and Ki-67 expression in NPC tissue. Results: β-Catenin was upregulated in NPC cell lines and tissues compared with chronic nasopharyngitis tissue. β-Catenin knockdown dramatically inhibited cellular growth, migration and invasion, but induced apoptosis of NPC cells. Further study showed that downstream genes of β-catenin signaling pathway including cyclin D1, c-Myc, MMP2 and MMP9 expression were suppressed in NPC cell lines transfected with β-catenin siRNA. Conclusion: Targeting β-catenin signaling pathway may be a noval strategy for NPC therapy. |
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Authors:
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Yulan Song; Qing Xu Yang; Fenfen Zhang; Fengjiao Meng; Hui Li; Yu Dong; Anjia Han |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-3 |
Journal Detail:
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Title: Cancer epidemiology Volume: - ISSN: 1877-783X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101508793 Medline TA: Cancer Epidemiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pathology, The First Affiliated Hospital and Zhongshan School of Medicine, Sun Yat-Sen University, 58, Zhongshan Road II, Guangzhou 510080, China; Department of Pathology, The First Affiliated Hospital, Guangdong University of Pharmacy, Guangzhou 510080, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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