Document Detail

Suppression of mixed lymphocyte reaction by progesterone and estradiol-17beta.
MedLine Citation:
PMID:  156501     Owner:  NLM     Status:  MEDLINE    
The effects of estrone, estradiol-17beta, estriol, testosterone, progesterone, and 20alpha-dihydroprogesterone on incorporation of 3H-thymidine into cultured lymphocytes from normal men and nonpregnant women in response to allogeneic stimulation was investigated with two-way MLR. A dose-dependent reduction in the mean percent incorporation was observed in the range of progesterone concentration between 2 x 10(3) and 10(4) ng/ml with statistically significant differences from the control cultures. Estradiol-17 beta at 10(4) ng/ml produced a slight but significant inhibition of incorporation. No significant change in incorporation occurred with the other steroids tested. Since the suppressive property of progesterone in phytohemagglutinin-induced lymphocyte culture reported in our previous communication was reproduced by the present investigation in MLR, the possible role of progesterone in immunoregulation during pregnancy is emphasized as has been postulated previously.
H Kobayashi; T Mori; A Suzuki; T Nishimura; H Nishimoto; M Harada
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  134     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-08-16     Completed Date:  1979-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-9     Citation Subset:  AIM; IM    
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MeSH Terms
20-alpha-Dihydroprogesterone / pharmacology
Dose-Response Relationship, Drug
Estradiol / pharmacology
Estriol / pharmacology
Estrone / pharmacology
Gonadal Steroid Hormones / pharmacology*
Immunosuppressive Agents / pharmacology
Lymphocyte Culture Test, Mixed
Lymphocytes / drug effects*,  metabolism
Progesterone / pharmacology
Testosterone / pharmacology
Thymidine / metabolism*
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Immunosuppressive Agents; 145-14-2/20-alpha-Dihydroprogesterone; 50-27-1/Estriol; 50-28-2/Estradiol; 50-89-5/Thymidine; 53-16-7/Estrone; 57-83-0/Progesterone; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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