Document Detail

Suppression of mitogenic response of bovine peripheral blood lymphocytes by ketone bodies.
MedLine Citation:
PMID:  7756418     Owner:  NLM     Status:  MEDLINE    
Mitogenic response of peripheral blood lymphocytes from ketotic cows and effect of ketone bodies on lymphocyte blastogenesis were investigated. Glucose consumption index (GCI) values for phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) in the ketotic cows were significantly lower than those in the healthy dry cows. A significant negative correlation was observed between the GCI values and serum concentrations of total ketone and beta-hydroxybutyric acid. When lymphocytes from healthy dry cows were preincubated in the medium with acetoacetic acid or beta-hydroxybutyric acid, the GCI values for PHA and PWM were significantly lower than those in the lymphocytes without ketone bodies. These findings indicate that increased serum concentrations of acetoacetic acid and beta-hydroxybutyric acid in ketotic cows suppress lymphocyte blastogenesis.
S Sato; T Suzuki; K Okada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  57     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  183-5     Citation Subset:  IM    
Veterinary Clinic and Training Center, Miyagi Prefectural Federation of Agricultural Mutual Aid Association, Japan.
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MeSH Terms
3-Hydroxybutyric Acid
Acetoacetates / blood
Cattle Diseases / blood,  immunology*
Hydroxybutyrates / blood
Ketone Bodies* / blood
Ketosis / blood,  immunology,  veterinary*
Lymphocyte Activation / physiology*
Reg. No./Substance:
0/Acetoacetates; 0/Hydroxybutyrates; 0/Ketone Bodies; 300-85-6/3-Hydroxybutyric Acid; 541-50-4/acetoacetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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