Document Detail

Suppression of lymphocyte response to concanavalin A by mucopolysaccharide material from Treponema pallidum-infected rabbits.
MedLine Citation:
PMID:  159264     Owner:  NLM     Status:  MEDLINE    
The testicular fluid and serum from rabbits infected intratesticularly with Treponema pallidum inhibited the mitogenic response of normal rabbit peripheral blood lymphocytes to concanavalin A. Mucopolysaccharide material present in the testicular fluid and serum was associated with the lymphocyte-inhibitory activity. Degradation of the mucopolysaccharide material with hyaluronidase resulted in the loss of the inhibitory activity of testicular fluid and serum of T. pallidu-infected rabbits.
R F Bey; R C Johnson; T J Fitzgerald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  26     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
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MeSH Terms
Concanavalin A
Glycosaminoglycans / blood,  physiology*
Hyaluronoglucosaminidase / pharmacology
Lymphocyte Activation*
Syphilis / blood,  immunology*
Reg. No./Substance:
0/Glycosaminoglycans; 11028-71-0/Concanavalin A; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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