| Suppression of lymphocyte activation by a protein released from isolated perfused rat liver. | |
| | |
MedLine Citation:
|
PMID: 6978837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Isolated rat liver perfusates contain a substance which inhibits 3H-thymidine uptake by phytohemagglutinin-stimulated human peripheral blood lymphocytes in a dose-dependent, noncytotoxic fashion. Suppression is not due to interference of lymphocyte-phytohemagglutinin interaction or dilution of the thymidine pool. Complete inhibition of thymidine uptake is achieved with less than 1.0 microgram of material per ml (which is a potentially achievable concentration in vivo). The release of this material is directly and quantitatively associated with hepatocellular injury as measured by release of glutamic pyruvate transaminase. The material is a highly basic protein with a molecular weight of approximately 65,000 to 80,000 daltons. It is a product of the hepatocyte rather than of nonparenchymal liver cells. Liver-derived materials, such as the presently described molecule, may play a role in in situ regulation of lymphocyte function during immunologically mediated liver disease. |
| | |
Authors:
|
C Pizzo; D Lee; F V Chisari |
Related Documents
:
|
659397 - Biochemical and ultrastructural evaluation of isolated rat liver systems perfused with ... 9755227 - Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic mi... 3911487 - Immunolocalization of factor v in adult and fetal rat liver. 16120197 - Hypothalamic antihypertensive effect of metoprolol in chronic aortic coarctated rats. 3055227 - Forestomach lesions induced by butylated hydroxyanisole and ethylene dibromide: a scien... 20817087 - Olive oil improved the impairment of in vitro insulin-stimulated glucose uptake by diap... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Hepatology (Baltimore, Md.) Volume: 2 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1982 May-Jun |
Date Detail:
|
Created Date: 1982-07-19 Completed Date: 1982-07-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 295-303 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine Transaminase
/
physiology Animals DNA / biosynthesis Liver / immunology, physiology* Lymphocyte Activation* Male Mice Mice, Inbred Strains Perfusion Phytohemagglutinins / metabolism Proteins / physiology* Rats Rats, Inbred Lew Thymidine / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
AI 13393/AI/NIAID NIH HHS; AI 17353/AI/NIAID NIH HHS; RCDA AI 00174/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Phytohemagglutinins; 0/Proteins; 50-89-5/Thymidine; 9007-49-2/DNA; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunological suppression of carcinogenesis in spontaneously hypertensive rats (SHR) with T-cell dep...
Next Document: Suppression of adjuvant arthritis by antibodies specific for collagen type II.