Document Detail

Suppression of local intestinal immunoglobulin A immune response to cholera toxin by subcutaneous administration of cholera toxoids.
MedLine Citation:
PMID:  457279     Owner:  NLM     Status:  MEDLINE    
Cholera toxin has been shown to modulate immune responses, generally producing enhancement when administered simultaneously with antigen and suppression when administered a day or more earlier. In a previous study using chronically isolated ileal loops in rabbits, we found that two subcutaneous (s.c.) "priming" and "boosting" doses of biologically active cholera toxin suppressed the local intestinal immunoglobulin A response to intraloop doses of cholera toxin. In the study reported here, two different biologically inactive but antigenically intact cholera toxoids, glutaraldehyde toxoid and choleragenoid, where administered s.c. by the same immunization schedule as for toxin in the earlier experiment. Suppression of local immune response to intraloop cholera toxin as compared with animals receiving no s.c. inoculations was again found. The results suggest that in this model suppression was immunological (mediated by an immunological mechanism) rather than toxigenic (mediated by biological activity of cholera toxin). In addition, the occurrence of suppression of local intestinal immune response after systemic immunization suggests that suboptimal protection against enteric infections could occur after s.c. vaccination.
S R Hamilton; J H Yardley; G D Brown
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  24     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
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MeSH Terms
Antibody Formation / drug effects
Antitoxins / biosynthesis*
Cholera Toxin / administration & dosage,  immunology,  pharmacology*
Immunoglobulin A / biosynthesis*
Injections, Subcutaneous
Lymphoid Tissue / immunology*
Peyer's Patches / immunology*
Reg. No./Substance:
0/Antitoxins; 0/Immunoglobulin A; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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