| Suppression of liver uptake of liposomes by dextran sulfate 500. | |
| | |
MedLine Citation:
|
PMID: 6195658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0-50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route. |
| | |
Authors:
|
K R Patel; M P Li; J D Baldeschwieler |
Related Documents
:
|
22757398 - Th-c-brb-10: clinical implication of the new dosimetry formalism in imrt quality assura... 7983678 - Autoprotection: stimulated tissue repair permits recovery from injury. 22830868 - Poster - thur eve - 52: clinical use of nanodots: in-vivo dosimetry and treatment valid... 3788368 - Effect of 3-methylcholanthrene on the protein composition of heterogeneous nuclear ribo... 22757398 - Th-c-brb-10: clinical implication of the new dosimetry formalism in imrt quality assura... 753628 - Therapy of ischemic brain edema. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 80 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1983 Nov |
Date Detail:
|
Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2010-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 6518-22 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport / drug effects Dextran Sulfate Dextrans / pharmacology* Kinetics Liposomes / administration & dosage*, metabolism Liver / metabolism* Macrophages / drug effects Mice Mononuclear Phagocyte System / drug effects Phagocytosis / drug effects Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
|
GM21111-09/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Liposomes; 9004-54-0/Dextrans; 9042-14-2/Dextran Sulfate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Keratin synthesis in normal mouse epithelia and in squamous cell carcinomas: evidence in tumors for ...
Next Document: Kpn I family of long-dispersed repeated DNA sequences of man: evidence for entry into genomic DNA of...