Document Detail

Suppression of liver uptake of liposomes by dextran sulfate 500.
MedLine Citation:
PMID:  6195658     Owner:  NLM     Status:  MEDLINE    
The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0-50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route.
K R Patel; M P Li; J D Baldeschwieler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  80     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6518-22     Citation Subset:  IM    
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MeSH Terms
Biological Transport / drug effects
Dextran Sulfate
Dextrans / pharmacology*
Liposomes / administration & dosage*,  metabolism
Liver / metabolism*
Macrophages / drug effects
Mononuclear Phagocyte System / drug effects
Phagocytosis / drug effects
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Liposomes; 9004-54-0/Dextrans; 9042-14-2/Dextran Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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