Document Detail

Suppression of immunological activities by mouse amniotic fluid.
MedLine Citation:
PMID:  75567     Owner:  NLM     Status:  MEDLINE    
Mouse amniotic fluid (MAF) was shown to be capable of suppressing those antibody responses observed in euthymic or athymic mouse spleen cell cultures to the T-independent antigens dinitrophenylated Ficoll (DNP-Ficoll) and trinitrophenylated lipopolysaccharide (TNP-LPS) and to the polyclonal B-cell activators LPS and purified protein derivative of tuberculin (PPD). Titration experiments demonstrated that the suppressive capacity of MAF for either LPS or DNP-Ficoll responses was maintained up to a MAF dilution of 1:120. Preincubation of spleen cells obtained from athymic mice with MAF for 8 h significantly suppressed polyclonal B-cell activation of such cells induced by LPS, although suppression was greater when MAF was present during the entire culture period. In addition, the suppressive activity that MAF demonstrated for antibody production induced by DNP-Ficoll or LPS was not lost as a result of dialysis. MAF also suppressed the secondary in vitro proliferative responses of lymph node cells sensitized to the T-dependent antigen human gamma globulin (HGG). HGG-induced proliferation of such cells appeared to be more susceptible to suppression effected by MAF than concanavalin-A-induced proliferation.
H M Etlinger; J M Chiller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  6     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1241-9     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / immunology*
Antibody Formation
Dinitrobenzenes / immunology
Dose-Response Relationship, Immunologic
Immunosuppressive Agents / pharmacology*
Lymphocytes / immunology
Mice, Inbred A
Mice, Nude
Spleen / immunology
Time Factors
Trinitrobenzenes / immunology
gamma-Globulins / immunology
Reg. No./Substance:
0/Dinitrobenzenes; 0/Immunosuppressive Agents; 0/Trinitrobenzenes; 0/gamma-Globulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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