Document Detail

Suppression of immunological activities by mouse amniotic fluid.
MedLine Citation:
PMID:  75567     Owner:  NLM     Status:  MEDLINE    
Mouse amniotic fluid (MAF) was shown to be capable of suppressing those antibody responses observed in euthymic or athymic mouse spleen cell cultures to the T-independent antigens dinitrophenylated Ficoll (DNP-Ficoll) and trinitrophenylated lipopolysaccharide (TNP-LPS) and to the polyclonal B-cell activators LPS and purified protein derivative of tuberculin (PPD). Titration experiments demonstrated that the suppressive capacity of MAF for either LPS or DNP-Ficoll responses was maintained up to a MAF dilution of 1:120. Preincubation of spleen cells obtained from athymic mice with MAF for 8 h significantly suppressed polyclonal B-cell activation of such cells induced by LPS, although suppression was greater when MAF was present during the entire culture period. In addition, the suppressive activity that MAF demonstrated for antibody production induced by DNP-Ficoll or LPS was not lost as a result of dialysis. MAF also suppressed the secondary in vitro proliferative responses of lymph node cells sensitized to the T-dependent antigen human gamma globulin (HGG). HGG-induced proliferation of such cells appeared to be more susceptible to suppression effected by MAF than concanavalin-A-induced proliferation.
H M Etlinger; J M Chiller
Related Documents :
1079037 - The stimulation of immunoglobulin production in murine spleen cells by the pokeweed mit...
8364167 - Opioid dependency and t-helper cell functions in rhesus monkey.
22242197 - Dynamic shift from cd85j/ilt-2 to nkg2d nk receptor expression pattern on human decidua...
21731677 - Daidzein prevents the increase in cd4+cd28null t cells and b lymphopoesis in ovariectom...
15451457 - Differences in f36vmpl-based in vivo selection among large animal models.
15548427 - Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2a cel...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  6     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1241-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / immunology*
Antibody Formation
Dinitrobenzenes / immunology
Dose-Response Relationship, Immunologic
Immunosuppressive Agents / pharmacology*
Lymphocytes / immunology
Mice, Inbred A
Mice, Nude
Spleen / immunology
Time Factors
Trinitrobenzenes / immunology
gamma-Globulins / immunology
Reg. No./Substance:
0/Dinitrobenzenes; 0/Immunosuppressive Agents; 0/Trinitrobenzenes; 0/gamma-Globulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Three new cases of an inborn qualitative fibrinogen defect (fibrinogen Oslo II).
Next Document:  Direct demonstration and quantitation of the first complement component in human serum.