Document Detail


Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma.
MedLine Citation:
PMID:  9105518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of systemic glucocorticoid therapy on immune parameters was studied in patients with bronchial asthma. Patients were divided into two groups: 1) those receiving oral glucocorticoid; 2) control patients who did not receive systemic glucocorticoid treatment. The glucocorticoid dose varied between 5 and 70 mg per day. Patients had been taking oral therapy for at least 1 year. Glucocorticoid treatment was associated with an increased frequency of respiratory tract infections. Therefore, we need to define immune parameters which may predict an increased risk of infections. In this study, we analyzed several surface markers on lymphocytes and monocytes by flow cytometry. A significant reduction of the ratio of peripheral blood CD4+ to CD8+ T cells was associated with the administration of oral glucocorticoids. Furthermore, the expression of the HLA-DR molecule on monocytes was reduced in patients with systemic glucocorticoid therapy compared to control patients. Moreover, the capacity to elaborate cytokines by peripheral blood mononuclear cells upon stimulation was greatly reduced after exposure to glucocorticoids in vivo and in vitro. In addition, the humoral immune response was affected, because reduced IgG, IgM, and IgA levels were observed in patients receiving oral glucocorticoids. These results indicate that systemic glucocorticoid treatment in patients with bronchial asthma is associated with cellular and humoral immunosuppression which results in an increased risk of bacterial and viral infections.
Authors:
A G Oehling; C A Akdis; A Schapowal; K Blaser; M Schmitz; H U Simon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  52     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-11     Completed Date:  1997-06-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  144-54     Citation Subset:  IM; X    
Affiliation:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Asthma / drug therapy*,  epidemiology
CD4-CD8 Ratio / drug effects
Cells, Cultured
Disease Susceptibility
Drug Administration Schedule
Eosinophils / drug effects
Female
Glucocorticoids / administration & dosage,  adverse effects*
HLA-DR Antigens / biosynthesis
Humans
Immune System / drug effects*
Immunoglobulins / biosynthesis,  drug effects
Immunosuppressive Agents / adverse effects*
Incidence
Interferon-gamma / biosynthesis
Interleukin-4 / biosynthesis
Interleukin-5 / biosynthesis
Leukocyte Count / drug effects
Lymphocyte Count / drug effects
Male
Middle Aged
Monocytes / immunology
Prednisone / administration & dosage,  adverse effects*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/HLA-DR Antigens; 0/Immunoglobulins; 0/Immunosuppressive Agents; 0/Interleukin-5; 207137-56-2/Interleukin-4; 53-03-2/Prednisone; 82115-62-6/Interferon-gamma
Comments/Corrections
Comment In:
Allergy. 1997 Feb;52(2):122-3   [PMID:  9105515 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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