| Suppression of hypercholesterolemia in hepatoma-bearing rats by cabbage extract and its component, S-methyl-L-cysteine sulfoxide. | |
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MedLine Citation:
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PMID: 9625597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of cabbage extract on cholesterol metabolism was studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A). The hepatoma-bearing rats exhibited hypercholesterolemia induced by increasing cholesterogenesis in the host liver and decreasing steroid excretion into feces. The cabbage extract intake or administration reduced serum cholesterol level and enhanced fecal bile acid excretion and cholesterol 7alpha-hydroxylase activity, the rate-limiting enzyme of bile acid biosynthesis, in the microsomal fraction of the liver. Furthermore, S-methyl-L-cysteine sulfoxide, a component of cabbage, could mimic the effect of cabbage extract when orally administered. These results suggest that cabbage suppresses hypercholesterolemia responding to hepatoma growth by upregulating cholesterol catabolism and that S-methyl-L-cysteine sulfoxide in cabbage is one of the factors suppressing hypercholesterolemia in the hepatoma-bearing rats. |
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Authors:
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W Komatsu; Y Miura; K Yagasaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 33 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-30 Completed Date: 1998-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-503 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Science, Tokyo Noko University, Fuchu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / pharmacology* Brassica* Cholesterol / blood, metabolism Cholesterol, HDL / blood Cholesterol, LDL / blood Cholesterol, VLDL / blood Cysteine / analogs & derivatives*, pharmacology Energy Intake Fatty Acids / metabolism Hypercholesterolemia / etiology*, metabolism, prevention & control* Liver / anatomy & histology, metabolism Liver Neoplasms, Experimental / blood, complications*, metabolism Male Organ Size Plant Extracts / pharmacology* Rats Rats, Inbred Strains Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Fatty Acids; 0/Plant Extracts; 4740-94-7/methiin; 52-90-4/Cysteine; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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