| Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig. | |
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MedLine Citation:
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PMID: 7446746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of furosemide on acid secretion and Cl- transport was studied in isolated fundic mucosa of the guinea pig. Furosemide (10(-3) M), applied to the serosal side produced an immediate effect on the short-circuit current (Isc), lowering it by 47 +/- 2%. Potential difference decreased by 29 +/- 3%, electrical conductance by 18 +/- 4%, acid secretion by 38 +/- 1%, and net flux of Cl- from serosal-to-mucosal side by 37%. Application of the drug to the mucosal side produced similar effects on acid secretion and on the electrical parameters. It is suggested that furosemide blocks the entrance of Cl-, by the Na+--Cl- cotransport mechanism, through the basolateral membrane of the secreting cell. The consequent reduction in electrogenic Cl- transport would cause Isc and acid secretion to decrease. A reduction of Cl- conductance of the apical membrane, upon mucosal application of the drug, would cause similar effects on acid secretion and Cl- transport. |
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Authors:
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A Ayalon; A Corcia; G Klemperer; S R Caplan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 239 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-02-26 Completed Date: 1981-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G532-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane Permeability / drug effects Chlorides / metabolism Furosemide / pharmacology* Gastric Acid / secretion* Gastric Mucosa / drug effects* Guinea Pigs |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 54-31-9/Furosemide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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