Document Detail

Suppression of food intake is linked to enteric inflammation in nematode-infected rats.
MedLine Citation:
PMID:  10644629     Owner:  NLM     Status:  MEDLINE    
Our aim was to investigate the cause-effect relationship between intestinal inflammation induced by infection with enteric stages of Trichinella spiralis and decreased host food intake. A suppression of food intake in T. spiralis-infected rats occurred within the first 24 h postinfection (PI) and was maximized by day 6 PI. Food intake, cumulated over an 8-day PI period, decreased by 59% compared with uninfected animals. The anti-inflammatory glucocorticoid betamethasone 21-phosphate was orally administered to rats in their drinking water to suppress T. spiralis-induced jejunal inflammation. When treated with a low dose of glucocorticoid (5.2 microg/ml), food intake in infected rats was still significantly reduced, but only by 21% compared with glucocorticoid-treated, uninfected rats. At the highest glucocorticoid dose (10.4 microg/ml) administered, infection-induced reduction in food intake was not different from that of glucocorticoid-treated, uninfected counterparts. The elevation in jejunal myeloperoxidase activity caused by infection was also significantly blunted by oral glucocorticoid treatment. Our results suggest that suppressed host food intake during enteric T. spiralis infection is directly linked to intestinal inflammation.
C J Faro; R D Reidelberger; J M Palmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  278     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R118-24     Citation Subset:  IM    
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha 68178, Nebraska.
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MeSH Terms
Administration, Oral
Anti-Inflammatory Agents / pharmacology
Betamethasone / pharmacology
Body Weight / drug effects
Drinking / drug effects
Eating* / drug effects
Enteritis / enzymology,  parasitology*,  pathology
Nematode Infections*
Peroxidase / metabolism
Rats, Sprague-Dawley
Reference Values
Trichinellosis / metabolism,  pathology,  physiopathology
Grant Support
Reg. No./Substance:
0/Anti-Inflammatory Agents; 378-44-9/Betamethasone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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