Document Detail

Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system.
MedLine Citation:
PMID:  10556053     Owner:  NLM     Status:  MEDLINE    
We have isolated a Drosophila mutant, named pumpless, which is defective in food intake and growth at the larval stage. pumpless larvae can initially feed normally upon hatching. However, during late first instar stage, they fail to pump the food from the pharynx into the esophagus and concurrently begin moving away from the food source. Although pumpless larvae do not feed, they do not show the typical physiologic response of starving animals, such as upregulating genes involved in gluconeogenesis or lipid breakdown. The pumpless gene is expressed specifically in the fat body and encodes a protein with homology to a vertebrate enzyme involved in glycine catabolism. Feeding wild-type larvae high levels of amino acids could phenocopy the feeding and growth defects of pumpless mutants. Our data suggest the existence of an amino acid-dependent signal arising from the fat body that induces cessation of feeding in the larva. This signaling system may also mediate growth transition from larval to the pupal stage during Drosophila development.
I Zinke; C Kirchner; L C Chao; M T Tetzlaff; M J Pankratz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  126     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5275-84     Citation Subset:  IM    
Institut für Genetik, Forschungszentrum Karlsruhe, Postfach 3640, Germany.
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MeSH Terms
Amino Acid Oxidoreductases / genetics*,  metabolism
Amino Acid Sequence
Amino Acids / metabolism,  pharmacology
Carrier Proteins / genetics*,  metabolism
Drosophila / embryology,  genetics*,  growth & development
Drosophila Proteins*
Eating / genetics*
Embryo, Nonmammalian
Fat Body / physiology*
Gene Expression Regulation, Developmental
Insect Proteins / genetics*,  metabolism*
Molecular Sequence Data
Multienzyme Complexes / genetics*,  metabolism
Sequence Homology, Amino Acid
Transferases / genetics*,  metabolism
Vertebrates / physiology
Reg. No./Substance:
0/Amino Acids; 0/Carrier Proteins; 0/Drosophila Proteins; 0/Insect Proteins; 0/Multienzyme Complexes; 0/glycine cleavage system; 0/pumpless protein, Drosophila; EC 1.4.-/Amino Acid Oxidoreductases; EC 2.-/Transferases

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